ABSTRACT
OBJECTIVE@#To explore the significance of chromosome 6 aberrations for the occurrence and prognosis of hematopathies.@*METHODS@#Clinical data and the cytogenetic results of 99 patients with hematopathies and aberrations of chromosome 6 were analyzed.@*RESULTS@#The patients mainly had acute lymphoblastic leukemia (ALL), lymphoma, multiple myeloma, and myelodysplastic syndrome. ALL was the most common among the selected disorders. Based on their main abnormalities, ALL patients were divided into +6/-6, 6p and 6q groups. No significant difference was found in the gender, hemoglobin and platelet count between the three groups (P> 0.05). The age and white cell count in those with 6q aberrations were significantly higher compared with the +6/-6 group (P< 0.05). Multivariate COX analysis suggested that the 6p/6q aberrations and age are risk factors for the prognosis. The 1-year overall survival rate of the 6p and 6q groups were lower than that of the +6/-6 group (P< 0.05).@*CONCLUSION@#Aberrations of chromosome 6 are common in B-cell disease, and patients with ALL and 6q aberration have a poorer prognosis. Analysis of chromosome 6 aberration has a significance for the prognosis.
ABSTRACT
Acute pancreatitis (AP) is an acute inflammatory and cell-damaging process of the pancreas. In this paper, using the AP onset location and its characteristics combined with review of the ancient and modern literatures and summary of the clinical practices, the professor Chen Qiaolin's academic ideas and clinical experiences in treating AP are introduced and demonstrated. Dr. Chen believes that the development of AP is a dynamic process, the key point is to grasp the Shaoyang syndrome complicated with Yangming, the internal administration of the self-modified Dachaihu decoction is the basic therapy accompanied by applying paste-like Traditional Chinese Medicine TCM attached on the acupoints and acupuncture for comprehensive treatment of AP, the therapeutic result is confirmed and its summary is as follows.